Abnormal functional connectivity between motor cortex and pedunculopontine 3 nucleus following chronic dopamine depletion
نویسندگان
چکیده
5 Miguel Valencia, Mario Chavez, Julio Artieda, J. Paul Bolam and Juan Mena-Segovia 6 7 1 Neurophysiology Laboratory, Neuroscience Area, CIMA, Universidad de Navarra, Pamplona, Spain 8 2 Institute du Cerveau et de la Moelle Epinière, Hôpital de La Pitié-Salpêtrière, Paris, France 9 3 MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, 10 Mansfield Road, Oxford OX1 3TH, United Kingdom 11 12 *Correspondence should be addressed to: 13 Juan Mena-Segovia: MRC Anatomical Neuropharmacology Unit, University of Oxford, Mansfield 14 Road, Oxford OX1 3TH, United Kingdom. Tel. +44 (0) 1865 281637 15 E-mail: [email protected]. 16 17 Number of figures: 3 18 Number of pages: 23 19 20 Abbreviations 21 6-OHDA, 6-hydroxydopamine; Coh, coherence; MCx, motor cortex; PD, Parkinson’s disease; PPN, 22 pedunculopontine nucleus. 23 24 Running title: Connectivity between cortex and PPN during parkinsonism 25 26
منابع مشابه
Abnormal functional connectivity between motor cortex and pedunculopontine nucleus following chronic dopamine depletion.
The activity of the basal ganglia is altered in Parkinson's disease (PD) as a consequence of the degeneration of dopamine neurons in the substantia nigra pars compacta. This results in aberrant discharge patterns and expression of exaggerated oscillatory activity across the basal ganglia circuit. Altered activity has also been reported in some of the targets of the basal ganglia, including the ...
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